[JohnK]

Not sure what the scientific explanation is but I find that the closer I am to the centre/front of the plane then the much better I feel.

I have travelled down the back of the plane on a few occassions and these have not been good experiences. I remember many years ago sitting in the last economy row seat on a flight SYD-MEL and it was one of the worst flights I ever had.

These days I have been quite lucky in that most of the time I book early enough and I get an aisle seat in the first couple of seats of economy. For me this is a pretty comfortable flight. Occassionally I venture down the back for a stretch and I am not very comfortable at all so quickly return to my forward aisle seat. I have met many people that find sitting in the back is a little more uncomfortable.